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Index > Protein center > MAGED1(Gene name) > Human
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  • MAGED1 (Gene name),
  • Melanoma-associated antigen D1 (Protein name ),  MAGD1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    MAGED1(PRO2292;PP2250;NRAGE);
    Protein name:
    Melanoma-associated antigen D1;
    Alternative:
    MAGE-D1 antigen;MAGE tumor antigen CCF;Neurotrophin receptor-interacting MAGE homolog;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A (By similarity). Interacts with the p75 neurotrophin receptor.
    Function:
    Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.
    Subcellular Location:
    Cytoplasm Cell membrane Peripheral membrane protein Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
    Protein Attributes:
    Sequence length:
    778
    Sequence:
    50:
    MAQKMDCGAG | LLGFQAEASV | EDSALLMQTL | MEAIQISEAP | PTNQATAAAS | 
    100:
    PQSSQPPTAN | EMADIQVSAA | AARPKSAFKV | QNATTKGPNG | VYDFSQAHNA | 
    150:
    KDVPNTQPKA | AFKSQNATPK | GPNAAYDFSQ | AATTGELAAN | KSEMAFKAQN | 
    200:
    ATTKVGPNAT | YNFSQSLNAN | DLANSRPKTP | FKAWNDTTKA | PTADTQTQNV | 
    250:
    NQAKMATSQA | DIETDPGISE | PDGATAQTSA | DGSQAQNLES | RTIIRGKRTR | 
    300:
    KINNLNVEEN | SSGDQRRAPL | AAGTWRSAPV | PVTTQNPPGA | PPNVLWQTPL | 
    350:
    AWQNPSGWQN | QTARQTPPAR | QSPPARQTPP | AWQNPVAWQN | PVIWPNPVIW | 
    400:
    QNPVIWPNPI | VWPGPVVWPN | PLAWQNPPGW | QTPPGWQTPP | GWQGPPDWQG | 
    450:
    PPDWPLPPDW | PLPPDWPLPT | DWPLPPDWIP | ADWPIPPDWQ | NLRPSPNLRP | 
    500:
    SPNSRASQNP | GAAQPRDVAL | LQERANKLVK | YLMLKDYTKV | PIKRSEMLRD | 
    550:
    IIREYTDVYP | EIIERACFVL | EKKFGIQLKE | IDKEEHLYIL | ISTPESLAGI | 
    600:
    LGTTKDTPKL | GLLLVILGVI | FMNGNRASEA | VLWEALRKMG | LRPGVRHPLL | 
    650:
    GDLRKLLTYE | FVKQKYLDYR | RVPNSNPPEY | EFLWGLRSYH | ETSKMKVLRF | 
    700:
    IAEVQKRDPR | DWTAQFMEAA | DEALDALDAA | AAEAEARAEA | RTRMGIGDEA | 
    750:
    VSGPWSWDDI | EFELLTWDEE | GDFGDPWSRI | PFTFWARYHQ | NARSRFPQTF | 
    778:
    AGPIIGPGGT | ASANFAANFG | AIGFFWVE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    UniGene:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Melanoma-associated antigen D1
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    ELISA Kit for Human Melanoma-associated antigen D1
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    E6073p
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    Packing:
    96T
    ELISA Kit for Human Melanoma-associated antigen D1
    Cat.:
    E6073r
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    Packing:
    96T
    ELISA Kit for Human Melanoma-associated antigen D1
    Cat.:
    E6073m
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    Packing:
    96T
    CLIA Kit for Human Melanoma-associated antigen D1
    Cat.:
    U6073h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Melanoma-associated antigen D1
    Cat.:
    U6073p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Melanoma-associated antigen D1
    Cat.:
    U6073m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Melanoma-associated antigen D1
    Cat.:
    U6073r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Melanoma-associated antigen D1
    Cat.:
    P6073Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Melanoma-associated antigen D1
    Cat.:
    P6073Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Melanoma-associated antigen D1
    Polyclonal Antibody for Human Melanoma-associated antigen D1
    Cat.:
    P6073Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Melanoma-associated antigen D1
    Monoclonal Antibody for Human Melanoma-associated antigen D1
    Monoclonal Antibody for Human Melanoma-associated antigen D1
    Monoclonal Antibody for Human Melanoma-associated antigen D1
    Protein for Human Melanoma-associated antigen D1
    Protein for Human Melanoma-associated antigen D1
    Protein for Human Melanoma-associated antigen D1
    Protein for Human Melanoma-associated antigen D1

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    References
    1. 1.
      "NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor dependent apoptosis."
      Salehi A.H. , Roux P.P. , Kubu C.J. , Zeindler C. , Bhakar A. , Tannis L.-L. , Verdi J.M. , Barker P.A.
      Neuron27:279-288(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation."
      Wen C.-J. , Xue B. , Qin W.-X. , Yu M. , Zhang M.-Y. , Zhao D.-H. , Gao X. , Gu J.-R. , Li C.-J.
      FEBS Lett.564:171-176(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    3. 3.
      "Identification and characterization of a new member of the MAGE gene family."
      Chen Y.
      Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Blood.
      tissue: Skin.
    6. 6.
      "Identification of a new, unorthodox member of the MAGE gene family."
      Pold M. , Zhou J. , Chen G.L. , Hall J.M. , Vescio R.A. , Berenson J.R.
      Genomics59:161-167(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-778 (ISOFORM 1)
      tissue: Bone marrow.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-778
      tissue: Testis.
    8. 8.
      "A new melanoma antigen-encoding gene subfamily in human chromosome X."
      Zhang C.G. , Xing G.C. , Wei H.D. , Yu Y.T. , He F.C.
      Yi Chuan Xue Bao28:197-203(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 396-778
      tissue: Fetal liver.
    9. 9.
      "Identification of the translational initiation codon in human MAGED1."
      Kubu C.J. , Goldhawk D.G. , Barker P.A. , Verdi J.M.
      Genomics70:150-152(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF THE TRANSLATIONAL INITIATION CODON
    10. 10.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-92;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."
      Doyle J.M. , Gao J. , Wang J. , Yang M. , Potts P.R.
      Mol. Cell39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TRIM28 AND PJA1
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